Disease Focus - Galvanize Therapeutics®
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Disease Focus

Galvanize believes the greatest opportunity for meaningful innovation lies where significant unmet clinical need affects large, underserved patient populations. We focus our technology and resources on diseases where existing treatment options leave too many patients without meaningful solutions, and where a fundamentally different approach has the potential to improve outcomes at scale.

19 million people are diagnosed with cancer each year — one of the world’s leading causes of death.

We are working to bring forward solutions that impact large patient populations who face poor outcomes.

Only 15% of lung cancer cases are currently found in the early stages,
when the survival rate is 53.5%*

Most lung cancer cases aren’t diagnosed until later stages,
when the survival rate is only 3.9%*

Every 2.5 min someone is
diagnosed with lung cancer*

Lung cancer, along with breast cancer, is the most common cancer*

Disease progression and treatment paradigms by stage

Stage I Stage II Stage IIIA Stage IIIB Stage IV
5-year survival 54% 35% 10-15% <5% <2%
Surgery
Radiotherapy
Chemotherapy
Targeted therapy
Immunotherapy
Focal ablation
Aliya® PEF

Currently investigating the use of Aliya PEF in conjunction with standard of care therapies to improve outcomes

Review Clinical Evidence

9 million people in the United States suffer from chronic bronchitis

With chronic bronchitis, the airways produce excess mucus, resulting in chronic cough and shortness of breath.

†Reference: CDC 2018. COPD Trends Brief – Prevalence | American Lung Association

Disease Progression

Chronic bronchitis develops after exposure to cigarette smoke, vaping, secondhand smoke, airborne chemicals, or other pollution and irritants.

Airway irritant exposure

1

Exposure to irritants, cigarette smoke, vaping liquid, or pollutants
Mucus production in the airway

2

Production of mucus to
expel irritants
Chronic airway inflammation

3

Chronic inflammation causes more mucus production

COPD patients with chronic bronchitis have a reduced quality of life, worse respiratory symptoms, and a higher risk of exacerbations compared to COPD patients without chronic bronchitis.

5-year mortality increases by nearly
30% with 3+ mucus plugs

64% worse
respiratory symptoms

1.4x more likely
to be awakened by cough

Currently treatment options for the symptoms of chronic bronchitis that directly target the cells that produce mucus are limited.

Review Clinical Evidence

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Important Notice:

Galvanize Therapeutics® is a medical device manufacturer, not a healthcare provider. The information submitted through this form will be used solely to connect you with a physician in your area who uses the Aliya® PEF System. Please do not submit protected health information (PHI) — including diagnosis, treatment history, or medical records — through this form.

The Aliya® PEF System (K212871, K233884, and K253826) is 510(k) cleared in the United States for the surgical ablation of soft tissue. Galvanize Therapeutics® does not promote the off-label use of its products and nothing herein is intended to promote an off-label use of the Aliya PEF System. The Aliya PEF System is a tool for the surgical ablation of soft tissue it is not intended to treat, cure, prevent, nor mitigate any specific disease or condition.

For questions about coverage or eligibility for this procedure, please consult your physician and insurance provider.

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