Diagnose. Stage. Intervene.
Aliya® PEF energy triggers regulated cell death, engaging the body’s molecular machinery to eliminate cells in a controlled manner.
High voltage, short duration electrical energy is delivered locally to induce cell death through non-thermal mechanisms.
Designed to expand clinical possibility
Safety & Predictability
Expands clinical use cases with low procedural risk
- Low procedural risk burden
- Predictable ablation zone
- Favorable safety profile including near sensitive structures
Immunogenic Potential
Mechanism that may activate a specific immune response
- Regulated cell death
- May activate a specific immune response
Clinical Flexibility
Compatible with existing workflows, tools, and standard of care intervention
- Compatible with treatment sequencing
- Can be performed at time of biopsy
- Endoscopic and percutaneous options
Aliya PEF in action
*These are singular case experiences provided for educational purposes only. Individual patient results may vary. For more information about the Aliya® System, please see the User Manual and IFU. The Aliya System is 510(k) cleared in the United States for the surgical ablation of soft tissue. Galvanize Therapeutics® does not promote the off-label use of its products and nothing herein is intended to promote an off-label use of the Aliya System. The Aliya System is a tool for the surgical ablation of soft tissues, and is not intended to treat, cure, prevent nor mitigate any specific disease nor condition.
Safety Profile
Safety and predictability that expands clinical use cases
Aliya PEF has been used in a variety of challenging clinical scenarios
- Predictable ablation with preservation of surrounding structures
- Procedural risk burden similar to biopsy
- Favorable safety profile including near sensitive structures
Predictable ablation with preservation of surrounding structures
Aliya PEF preserves surrounding tissue structures.
- Non-thermal mechanism of action
- Not susceptible to heat sink effects or unintended thermal damage
- Preserves extracellular matrix
- Supports ablation near airways and other sensitive anatomy
References on file; studies conducted using the Aliya 2.5 generator.
In clinical studies, the procedural risk burden was similar to that of a diagnostic biopsy.
In clinical studies, Aliya PEF had a favorable safety profile including near sensitive structures.
IMMUNOGENIC POTENTIAL
Early signals of the potential for immune activation
In early, exploratory analyses, signals associated with immune activation have been observed.
Evidence of immune activation observed across multiple studies
Presence of biomarkers associated with up-regulation of the immune system have been observed in exploratory analyses.
Clinical flexibility
Clinical flexibility that integrates into practice
Aliya PEF integrates into existing procedural workflows and standard of care treatment sequencing
Aliya PEF clinical use
Aliya PEF has been used in a variety of clinical scenarios and anatomic locations.
Registration required. Access clinical data and case experience.
1 Percutaneous | 2 Endoscopic
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