Data
Galvanize Therapeutics has conducted years of intensive research to elucidate the impact of its pulsed electric field technology on core biological processes.
Ongoing research is focused on developing energy into therapies for airway disease, cardiac arrhythmias, and oncology.
Pipeline

Phase III
Available
Disease
Bronchitis
arrHythmias
Persistant AF
Clinical Trials
Chronic Bronchitis
ACTIVE NOT RECRUITING
Atrial Fibrillation
Oncology
Bronchial Rheoplasty
Publications
Abstracts
F. Sciurba, A. Comellas, A. Majid, K. Hogarth, N. Marchetti, V. Kim, M. Dransfield. Bronchial Rheoplasty for Chronic Bronchitis: 2 Year Results from a US Feasibility Study with RheOx. Am J Respir Crit Care Med 2022;205:A5598.
https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2022.205.1_MeetingAbstracts.A5598
D. Dorscheid, T. Shaipanich, M. Liberman, S. Martel, Marc Fortin. Bronchial Rheoplasty for Chronic Bronchitis: Results from A Canadian Feasibility Study with RheOx. Chest, Volume 160, Issue 4, Supplement, October 2021, Page A1860. https://www.sciencedirect.com/science/article/pii/S0012369221031135
V. Kim, G. Criner, F. Sciurba, A. Comellas, A. Majid, K. Hogarth, N. Marchetti, M. Dransfield. Impact of Bronchial Rheoplasty on exacerbations in chronic bronchitis: a US feasibility study. European Respiratory Journal Sep 2021, 58 (suppl 65) PA2131; DOI: 10.1183/13993003.congress-2021.PA2131. https://erj.ersjournals.com/content/58/suppl_65/PA2131
V. Kim, W. Krimsky, B. Bannan. Bronchial Rheoplasty improves respiratory and sleep symptoms in chronic bronchitis. European Respiratory Journal Sep 2021, 58 (suppl 65) PA2132; DOI: 10.1183/13993003.congress-2021.PA2132. https://erj.ersjournals.com/content/58/suppl_65/PA2132
F.C. Sciurba , A.P. Comellas, A. Majid , D.K. Hogarth, N. Marchetti, V. Kim, G.J. Criner, M.T. Dransfield. Bronchial Rheoplasty for Chronic Bronchitis: Results from a US Feasibility Study with RheOx. American Journal of Respiratory and Critical Care Medicine 2021;203:A2263. https://www.atsjournals.org/doi/10.1164/ajrccm-conference.2021.203.1_MeetingAbstracts.A2263
A. Valipour, S. Fernandez-Bussy, D. Steinfort, A. Ing, G. Snell. Bronchial Rheoplasty Treatment for Chronic Bronchitis Using the Rheox System: 12-Month Results of a Prospective, Multi-Center Study. American Journal of Respiratory and Critical Care Medicine 2020;201:A4312 https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2020.201.1_MeetingAbstracts.A4312
Valipour, A., Ing, A., Williamson, J., et al. Late Breaking Abstract – Bronchial Rheoplasty For Treatment of Chronic Bronchitis: 6 Month Results from a Prospective Multi-Center Study. European Respiratory Journal 2019; 54: Suppl. 63, RCT448. https://erj.ersjournals.com/content/54/suppl_63/RCT448?utm_source=TrendMD&utm_medium=cpc&utm_campaign=_European_Respiratory_Journal_TrendMD_0
Kim, V. et al. Bronchial Rheoplasty Increases Distal Airway Volume in Chronic Bronchitis. European Respiratory Journal 2019; 54: Suppl. 63, PA2040. https://erj.ersjournals.com/content/54/suppl_63PA2040.short?utm_source=TrendMD&utm_medium=cpc&utm_campaign=_European_Respiratory_Journal_TrendMD_0
Valipour, A., Ing, A., Williamson, J., et al. First-in-Human Results of Bronchial Rheoplasty: An Endobronchial Treatment for Chronic Bronchitis (CB). American Journal of Respiratory and Critical Care Medicine 2019;199:A7037.
https://www.atsjournals.org/doi/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A7037
Fernandez-Bussy, S., VanderLaan, P., Ing, A., Williamson, J. et al. Histopathologic Results Post Bronchial Rheoplasty. American Journal of Respiratory and Critical Care Medicine 2019;199:A7043. https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A7043
Valipour, A., Ing, A., Williamson, J., et al. Late Breaking Abstract – First-in-Human Results of Bronchial Rheoplasty: An Endobronchial Treatment for Chronic Bronchitis (CB). European Respiratory Journal 2018 52: Suppl. 62, OA2162. https://erj.ersjournals.com/content/52/suppl_62/OA2162?utm_source=TrendMD&utm_medium=cpc&utm_campaign=_European_Respiratory_Journal_TrendMD_0
Atrial Fibrillation
Publications
Verma A, Neal R, Evans J, et al. Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheter. J Cardiovasc Electrophysiol. 2022;1-9. doi:10.1111/jce.15734
https://onlinelibrary.wiley.com/doi/full/10.1111/jce.15734
Abstracts
R. Neal, Q. Castellvi, J. Evans. Biphasic Focal Monopolar Pulsed Electric Field Therapy: Preserved Phrenic Nerve Function and Anatomy. Heart Rhythm Vol. 18 Issue 8 Supplement S4–S5. August 2021
https://www.heartrhythmjournal.com/article/S1547-5271(21)00559-2/fulltext#relatedArticles
Q. Castellvi, R. Neal. Bipolar versus Monopolar Electrode Configuration Affects Treatment Depth in Pulsed Electric Field Ablation. HRS 2021.
H. Nakagawa, Q. Castellvi, R. Neal. Effects of Contact Force on Lesion Size During Pulsed Field Ablation. Heart Rhythm Vol. 18 Issue 8 SupplementS242–S243. August 2021.
https://www.heartrhythmjournal.com/article/S1547-5271(21)00923-1/fulltext
H. Nakagawa, Q. Castellvi, R. Neal, S. Girouard, S. Kuroda, A. Hussein, W. Saliba, O. Wazni. Histological Characterization of Reversible and Irreversible Ventricular Lesion Boundaries Produced by Pulsed Field Ablation. Heart Rhythm Vol. 18 Issue 8 Supplement S151–S152. August 2021.
https://www.heartrhythmjournal.com/article/S1547-5271(21)00923-1/fulltext
Q. Castellvi, R. Neal. The Influence of Heterogeneous Environments on Pulsed Electric Field Therapy Effects: Implications in Cardiac Ablation. Heart Rhythm Vol. 18 Issue 8 Supplement S372. August 2021.
https://www.heartrhythmjournal.com/article/S1547-5271(21)01461-2/fulltext
Q. Castellvi, R. Neal, A. Vachani, S. Girourd, J. Evans. The Susceptibility and Recovery of Esophageal Tissue Layers to Pulsed Electric Fields. Heart Rhythm Vol. 18 Issue 8 Supplement S72 Published in issue: August 2021.
https://www.heartrhythmjournal.com/article/S1547-5271(21)00736-0/fulltext
H. Nakagawa, Q. Castellvi, R. Neal, S. Girouard, Y. An, A. Hussein, W. Saliba, O. Wazni. Assessment of Lesion Durability Produced by Pulsed Electric Field Ablation: Evaluation in a Swine Atrial Linear Lesion Model. Heart Rhythm Vol. 19 Issue 5 Supplement S475. May 2022
https://www.heartrhythmjournal.com/article/S1547-5271(22)01347-9/fulltext
U. Sandhu, L. Alkukhun, B. Khieri, J. Hodovan, S. Giraud, K. Chiang, Q. Castellvi, Y. Zhao, B. Nazer. In-Vivo Pulsed Field Ablation in Healthy versus Chronically Infarcted Ventricular Myocardium: Biophysical and Histologic Characterization. Heart Rhythm Volume 19 Issue 5 S340 – S341. May 2022
https://www.heartrhythmjournal.com/article/S1547-5271(22)00677-4/fulltext
H. Nakagawa, Q. Castellvi, R. Neal, S. Girouard, Y. An, A. Hussein, W. Saliba, O. Wazni. Temporal and Spatial Evolution of Reversible and Irreversible Ventricular Lesion Boundaries Produced by Pulsed Electric Field Ablation. Heart Rhythm Vol. 19 Issue 5 Supplement S473–S474. May 2022
https://www.heartrhythmjournal.com/article/S1547-5271(22)01344-3/fulltext
A. Verma, Y. Khaykin, P. Sanchez-Samonte, J. Kittichamroen. Pulmonary Vein Isolation (PVI) and Posterior Wall Isolation (PWI) for Atrial Fibrillation Using Adjustable Focal Pulsed Electric Fields: SPACE AF Acute Results. Heart Rhythm Vol. 19 Issue 5 Supplement S416–S417. May 2022
https://www.heartrhythmjournal.com/article/S1547-5271(22)01215-2/fulltext
A. Verma, Q. Castellvi, A. Vachani, R. Neal, M. Terricabras. Thermal Profile for Pulsed Electric Field with the Centauri System using a Thigh Preparation Model. HRS 2022
Oncology
Publications
Abstracts
M. Silvestrini, C. Pastori, S. Tamakloe, T. O’Brien, C. Allen, R. Neal. Synergy of Local Treatment with Pulsed Electric Fields and Anti-PD1 Checkpoint Blockade. IASLC 2022. Vienna, AT.
M. Jimenez, J. M. Fernandez, J. Flandes Aldeyturriaga, E. van der Heijden, W. Krimsky. Focal Treatment of Early Stage NSCLC Using Pulsed Electric Fields: INCITE ES Study. SIR 2022. Boston, MA.
M. Silvestrini, S. Tamakloe, C. Pastori, T. O’Brien, R. Neal. Local Treatment with Pulsed Electric Fields Generates a Tumor Specific Response. Journal of Vascular and Interventional Radiology Vol. 33 Issue 6 Supplement S161–S162. June 2022.
https://www.jvir.org/article/S1051-0443(22)00592-9/fulltext
T. O’Brien, W. Krimsky, R. Neal. The Safety of Transbronchial and Percutaneous Delivery of Pulsed Electric Fields in Lung. ATS 2022. San Francisco, CA.
https://www.abstractsonline.com/pp8/#!/10476/presentation/10385
M. Jimenez. Focal Treatment of Early Stage NSCLC Using Pulsed Electric Fields: Safety and 30-Day Results from the INCITE ES Study. SIO 2022. San Francisco, CA.
C. Pastori, T. O’Brien, M. Silvestrini, R. Neal. Primary and Secondary Tumor Response to Combined Delivery of PEF and aPD-1 within 4T-1 and EMT-6 Orthotopic Tumor Models. SIO 2022. San Francisco, CA.
M. Silvestrini, C. Pastori, T. O’Brien, R. Neal. Immunogenicity of Pulsed Electric Fields is Enhanced with the Inclusion of Checkpoint Inhibitor Therapy. SIO 2022. San Francisco, CA.