Aliya™ PEF System

The Aliya™ PEF System is 510(k) cleared in the United States for the surgical ablation of soft tissue. It is not currently commercially available in any other geography.

Galvanize Therapeutics® does not promote the off-label use of its products and nothing herein is intended to promote an off-label use of the Aliya System. The Aliya System is a tool for the surgical ablation of soft tissues, and is not intended to treat, cure, prevent or mitigate any specific disease or condition.

The Aliya Pulsed Electric Field (PEF) System delivers high voltage, short duration electrical energy locally to alter the transmembrane potential of a cell, disrupting cellular homeostasis and inducing non-thermal programmed cell death.

Key Benefits:

Straightforward, Predictable Ablation with a single 19-guage needle and monopolar electrode for a precise and consistent ablation zone unaffected by heat sink effects.1

PEF delivered near the pleural surface

Preserves Surrounding Tissue
Aliya induces cell death through non-thermal mechanisms, leaving the extracellular matrix intact and preserving surrounding healthy tissue.2

Potential Immune Activation
Galvanize’s preclinical and early clinical trial data suggest the non-thermal cell death induced by PEF may release antigens from the dying tumor cells that may stimulate an immune response for a systemic effect beyond focal ablation. This may be synergistic with and additive to standard of care therapies.3,4,5,6

Aliya™ PEF Animation

Play Video


  1. TR-00107 Galvanize pre-clinical safety evaluation summary report. 2021.
  2. Internal data on file. TR-00158 Lab 90.
  3. HMGB1 study – Lab 179
  4. M. Silvestrini, et al. Local Treatment with Pulsed Electric Fields Generates a Tumor Specific Response. Journal of Vascular and Interventional Radiology. Vol. 33 Issue 6 Supplement S161–S162. June 2022.
  5. J. Iding, et al. Tertiary lymphoid structures (TLS) observed in non-small cell lung cancer (NSCLC) tumors treated with Pulsed Electric Fields. Journal for Immunotherapy of Cancer 2022;10(Suppl 2):A1–A1595.
  6. M. Jimenez, et al. Pulsed Electric Fields Induce a Stepwise Activation of Host Anti-Tumor Immunity in Patients with Early-Stage Non-Small Cell Lung Cancer. Journal for Immunotherapy of Cancer 2023;11(Suppl 1):A1–A1686.
Reimbursement Support
For assistance, email [email protected].