Aliya™ PEF System

The Aliya™ PEF System is 510(k) cleared in the United States for the surgical ablation of soft tissue. It is not currently commercially available in any other geography.

Galvanize Therapeutics® does not promote the off-label use of its products and nothing herein is intended to promote an off-label use of the Aliya System. The Aliya System is a tool for the surgical ablation of soft tissues, and is not intended to treat, cure, prevent or mitigate any specific disease or condition.

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The Aliya Pulsed Electric Field (PEF) System delivers high voltage, short duration electrical energy locally to alter the transmembrane potential of a cell, disrupting cellular homeostasis and inducing non-thermal programmed cell death.

Key Benefits:

Straightforward, Predictable Ablation with a single 19-guage needle and monopolar electrode for a precise and consistent ablation zone unaffected by heat sink effects.1

PEF delivered near the pleural surface

Preserves Surrounding Tissue
Aliya induces cell death through non-thermal mechanisms, leaving the extracellular matrix intact and preserving surrounding healthy tissue.2

Potential Immune Activation
Galvanize’s preclinical and early clinical trial data suggest the non-thermal cell death induced by PEF may release antigens from the dying tumor cells that may stimulate an immune response for a systemic effect beyond focal ablation. This may be synergistic with and additive to standard of care therapies.3,4,5,6

Aliya™ PEF Animation

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References:

  1. TR-00107 Galvanize pre-clinical safety evaluation summary report. 2021.
  2. Internal data on file. TR-00158 Lab 90.
  3. HMGB1 study – Lab 179
  4. M. Silvestrini, et al. Local Treatment with Pulsed Electric Fields Generates a Tumor Specific Response. Journal of Vascular and Interventional Radiology. Vol. 33 Issue 6 Supplement S161–S162. June 2022.
  5. J. Iding, et al. Tertiary lymphoid structures (TLS) observed in non-small cell lung cancer (NSCLC) tumors treated with Pulsed Electric Fields. Journal for Immunotherapy of Cancer 2022;10(Suppl 2):A1–A1595.
  6. M. Jimenez, et al. Pulsed Electric Fields Induce a Stepwise Activation of Host Anti-Tumor Immunity in Patients with Early-Stage Non-Small Cell Lung Cancer. Journal for Immunotherapy of Cancer 2023;11(Suppl 1):A1–A1686.

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